Bcl-6 (Rabbit Polyclonal)


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2 ml (Prediluted)

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Species: Rabbit
Clone: Polyclonal
Species Reactivity: Human, Mouse, and Rat.
Specificity: This antibody reacts with Bcl-6 of mouse, rat and human cell origin. Relatively little is known regarding the molecular pathogenesis of diffuse large-cell lymphoma (DLCL). DLCL accounts for approximately 40% of all non-Hodgkin lymphomas. Chromosomal translocations involving reciprocal recombination between band 3q27 and several other chromsomal sites are involved in 8 to 12% of non-Hodgkin's lymphomas; a breakpoint cluster region at 3q27 has been identified and designated bcl-6. More recently this gene has been shown to encode a protein of 706 aminio acids with predicted molecular weight of 79 kD. This Vcl-6 protein has homology with zinc finger-transcription factors and was found to be rearranged in 13 of 39 DLCL samples.

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